Angiogenesis, sprouting of new blood vessels from pre-existing vasculatures, plays a critical role in regulating tumor growth. Binding interactions between integrin, a heterodimeric transmembrane glycoprotein receptor, and its extracellular matrix ECM protein ligands govern the angiogenic potential of tumor endothelial cells. Integrin receptors are attractive targets in cancer therapy due to their overexpression on tumor endothelial cells, but not on quiescent blood vessels. These receptors are finding increasing applications in anti-angiogenic therapy via targeted delivery of chemotherapeutic drugs and nucleic acids to tumor vasculatures.
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The purpose of this study is to shed light on the origins of the endogenous money theory and analyze the current debates on this topic. Endogenous money approach depends on a fundamental postulate: As banks meet the credit needs of non-financial businesses, new deposits emerge in the banking sector. Similarly, as the necessary reserves found for these new deposits the broad money expands as well. Even though the central bank can intervene into this process it cannot fully control it.